Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors,Organic & Biomolecular Chemistry

当前位置： X-MOL 学术 › Org. Biomol. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1039/c7ob02040f
Abith Vattekkatte _{1,

2,

3,

4,

5} , Stefan Garms _{1,

2,

3,

4,

5} , Wolfgang Brandt _{1,

5,

6,

7} , Wilhelm Boland _{1,

2,

3,

4,

5}

Affiliation

The enormous diversity of terpenes found in nature is generated by enzymes known as terpene synthases, or cyclases. Some are also known for their ability to convert a single substrate into multiple products. This review comprises monoterpene and sesquiterpene synthases that are multiproduct in nature along with the regulation factors that can alter the product specificity of multiproduct terpene synthases without genetic mutations. Variations in specific assay conditions with focus on shifts in product specificity based on change in metal cofactors, assay pH and substrate geometry are described. Alterations in these simple cellular conditions provide the organism with enhanced chemodiversity without investing into new enzymatic architecture. This versatility to modulate product diversity grants organisms, especially immobile ones like plants with access to an enhanced defensive repertoire by simply altering cofactors, pH level and substrate geometry.

中文翻译：

萜类生物合成中增强的结构多样性：酶，底物和辅因子

在自然界中发现的萜烯种类繁多，是由称为萜烯合酶或环化酶的酶产生的。还有些以将单个基材转换为多种产品的能力而闻名。这篇综述包括本质上是多产品的单萜和倍半萜合酶，以及可以改变无遗传突变的多产品萜合酶的产品特异性的调节因子。描述了特定测定条件的变化，重点是基于金属辅因子的变化，测定pH和底物几何形状的产物特异性的变化。这些简单细胞条件的改变为生物提供了增强的化学多样性，而无需投资新的酶结构。这种调节产品多样性的多功能性使生物体，

更新日期：2017-12-18

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11