Dopamine is thought to play a crucial role in value-based decision making. However, the specific contributions of different dopamine receptor subtypes to the computation of subjective value remain unknown. Here we demonstrate how the balance between D1 and D2 dopamine receptor subtypes shapes subjective value computation during risky decision making. We administered the D2 receptor antagonist amisulpride or placebo before participants made choices between risky options. Compared with placebo, D2 receptor blockade resulted in more frequent choice of higher risk and higher expected value options. Using a novel model fitting procedure, we concurrently estimated the three parameters that define individual risk attitude according to an influential theoretical account of risky decision making (prospect theory). This analysis revealed that the observed reduction in risk aversion under amisulpride was driven by increased sensitivity to reward magnitude and decreased distortion of outcome probability, resulting in more linear value coding. Our data suggest that different components that govern individual risk attitude are under dopaminergic control, such that D2 receptor blockade facilitates risk taking and expected value processing.

中文翻译：

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多巴胺受体对价值计算的特定贡献。


多巴胺被认为在基于价值的决策中发挥着至关重要的作用。然而，不同多巴胺受体亚型对主观价值计算的具体贡献仍然未知。在这里，我们演示了 D1 和 D2 多巴胺受体亚型之间的平衡如何在风险决策过程中影响主观价值计算。在参与者在危险选项之间做出选择之前，我们给予 D2 受体拮抗剂氨磺必利或安慰剂。与安慰剂相比，D2 受体阻断导致更频繁地选择更高风险和更高期望值的选项。使用新颖的模型拟合程序，我们根据风险决策的有影响力的理论解释（前景理论）同时估计了定义个人风险态度的三个参数。该分析表明，观察到的氨磺必利风险厌恶的减少是由于对奖励幅度的敏感性增加和结果概率失真的减少所驱动的，从而导致更线性的值编码。我们的数据表明，控制个人风险态度的不同成分受到多巴胺能的控制，因此 D2 受体阻断有利于冒险和期望值处理。