AbstractThe authors describe new bifunctional mesoporous silica nanoparticles (NPs) for specific targeting of tumor cells and for intracellular delivery of the cancer drug doxorubicin (DOX). Mesoporous silica nanoparticles (MSNPs) were coated with blue fluorescent N-graphene quantum dots, loaded with the drug DOX, and finally coated with hyaluronic acid (HA). Cellular uptake of the NPs with an architecture of the type HA-DOX-GQD@MSNPs enabled imaging of human cervical carcinoma (HeLa) cells via fluorescence microscopy. The cytotoxicity of the nanoparticles on HeLa cells was also assessed. The results suggest that the NPs are higher cytotoxicity effect and exert in living cell imaging ability. Compared to the majority of other drug nanocarrier systems, the one described here enables simultaneous DOX release and fluorescent monitoring. Graphical abstractSchematic of the bifunctional mesoporous silica nanoparticles were obtained via the Stöber method, along with the doxorubicin loaded and the hyaluronic acid capped. The sensor shows good specificity and significant cytotoxicity effect on Hela cells. (TEOS: tetraethyl orthosilicate; GQDs: graphene quantum dots; DOX: doxorubicin; HA: Hyaluronic acid).

中文翻译：

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透明质酸修饰的 N 掺杂石墨烯量子点@介孔二氧化硅纳米粒子用于肿瘤细胞的荧光成像和药物递送

摘要作者描述了新的双功能介孔二氧化硅纳米粒子 (NPs)，用于特异性靶向肿瘤细胞和细胞内递送抗癌药物阿霉素 (DOX)。介孔二氧化硅纳米粒子（MSNPs）涂有蓝色荧光N-石墨烯量子点，负载药物DOX，最后涂有透明质酸（HA）。具有 HA-DOX-GQD@MSNPs 类型结构的 NPs 的细胞摄取能够通过荧光显微镜对人宫颈癌 (HeLa) 细胞进行成像。还评估了纳米颗粒对 HeLa 细胞的细胞毒性。结果表明，纳米颗粒具有较高的细胞毒性作用并发挥活细胞成像能力。与大多数其他药物纳米载体系统相比，这里描述的系统能够同时释放 DOX 和荧光监测。图形摘要通过 Stöber 方法获得了双功能介孔二氧化硅纳米粒子的示意图，以及加载的阿霉素和封端的透明质酸。该传感器对Hela细胞显示出良好的特异性和显着的细胞毒作用。（TEOS：原硅酸四乙酯；GQD：石墨烯量子点；DOX：阿霉素；HA：透明质酸）。