Sensitive ratiometric detection of Al(iii) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor†,New Journal of Chemistry

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Sensitive ratiometric detection of Al(iii) ions in a 100% aqueous buffered solution using a fluorescent probe based on a peptide receptor†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1039/c7nj04160h
Gi Won Hwang _{1,

2,

3} , Jongyong Jeon _{1,

2,

3} , Lok Nath Neupane _{1,

2,

3} , Keun-Hyeung Lee _{1,

2,

3}

Affiliation

Ratiometric detection of Al(III) ions in aqueous buffered solutions is still a significant challenge. Herein, a fluorescent probe 1 based on a dipeptide receptor bearing a pyrene fluorophore was synthesized by solid phase synthesis for the ratiometric detection of Al(III) ions in aqueous solutions. The peptidyl bioprobe detected Al(III) ions sensitively in a 100% aqueous buffered solution through ratiometric response. Upon the addition of Al(III) ions, the excimer emission at 476 nm increased significantly, and the monomer emission at 395 nm decreased considerably. Approximately 3.5 equiv. of Al(III) was required for the complete ratiometric response of 1. Moreover, 1 showed linear responses to nanomolar concentrations (0–500 nM) of Al(III) by change in the intensity ratio of the excimer and monomer emissions. The detection limit of 1 for Al(III) was 138.1 nM (R² = 0.980) in 100% aqueous solutions. The probe showed highly selective response to Al(III) in the presence of 16 metal ions. The fluorescent peptidyl probe was suitable for the ratiometric detection of Al(III) ions in ground water, tap water, and urine.

中文翻译：

使用基于肽受体的荧光探针灵敏地定量检测100％缓冲水溶液中的Al（iii）离子†

水溶液缓冲溶液中Al（III）离子的比例检测仍然是一项重大挑战。在本文中，通过固相合成合成了基于带有荧光团的二肽受体的荧光探针1，用于比例检测水溶液中的Al（III）离子。肽基生物探针通过比例响应在100％水性缓冲溶液中灵敏地检测到Al（III）离子。加入Al（III）离子后，在476 nm处的准分子发射显着增加，而在395 nm处的单体发射显着下降。约3.5当量完整的比例响应为1需要Al（III）的。此外，通过准分子和单体发射强度比的变化，1对纳摩尔浓度（0-500 nM）的Al（III）表现出线性响应。的检测极限1为铝（III）为138.1纳米（- [R ² = 0.980）在100％的水溶液。在存在16种金属离子的情况下，探针显示出对Al（III）的高度选择性响应。荧光肽基探针适用于比例测定地下水，自来水和尿液中的Al（III）离子。

更新日期：2017-12-18

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