pH is sometimes fundamental to the formation of coordination compounds. Here we report two new Zn(II)-tetrazole-carboxylate coordination compounds derived from Hatzipa, namely two dimensional [Zn(atzipa)₂]_n (1) and [Zn(atzipa)₂(H₂O)(EtOH)]_n (2), where Hatzipa = 5-aminotetrazole-1-isopropanoic acid. The structures of the two compounds are controlled by pH value of the reaction system. Compound 1 crystallizes in an achiral space group while 2 in a chiral space group P2(1)2(1)2. Furthermore, nanoparticles (NPs) of the two compounds can be obtained by co-precipitation with PEG_-5000 (Polyethylene Glycol_-5000). And [Zn(atzipa)₂]_n (1) NPs with a relatively low IC₅₀ (half-maximal inhibitory concentration) on Hela cells of 23 μg/mL (6.1 μM) is superior to [Zn(atzipa)₂(H₂O)(EtOH)]_n (2) NPs (58 μg/mL, 13.2 μM). Both NPs of the two compounds can inhibit the migration of Hela cells and compound 1NPs can be used as a cell imaging agent. The results show that pH influences the resulting structures and [Zn(atzipa)₂]_n (1) NPs capable of inhibiting the growth of tumor in vitro may be a potential candidate against cancer.

pH有时对于配位化合物的形成至关重要。在这里，我们报告了从Hatzipa衍生的两个新的Zn（II）-四唑-羧酸盐配位化合物，即二维[Zn（atzipa）₂ ] _n（1）和[Zn（atzipa）₂（H ₂ O）（EtOH）] _n（2），其中Hatzipa ＝ 5-氨基四唑-1-异丙酸。两种化合物的结构由反应体系的pH值控制。化合物1在非手性空间群中结晶，而化合物2在手性空间群P2（1）2（1）2中结晶。此外，可以通过与PEG _-5000共沉淀获得两种化合物的纳米颗粒（NPs）（聚乙二醇_-5000）。并且[Zn（atzipa）₂ ] _n（1）NPs在Hela细胞上的IC ₅₀相对较低（半数最大抑制浓度）为 23μg/ mL（6.1μM  ），优于[Zn（atzipa）₂（H ₂ O）（EtOH）] _n（2）NP（ 58μg/ mL， 13.2μM）。两种化合物的两个NP都可以抑制Hela细胞的迁移，化合物1NP可以用作细胞显像剂。结果表明，pH影响所得的结构和[Zn（atzipa）₂ ] _n（1能够在体外抑制肿瘤生长的NPs可能是抗癌的潜在候选药物。