The genetic architecture of dementia with Lewy bodies is shaping up,The Lancet Neurology

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The genetic architecture of dementia with Lewy bodies is shaping up
The Lancet Neurology ( IF 46.5 ) Pub Date : 2018-01-01 , DOI: 10.1016/s1474-4422(17)30411-8
Myriam Fornage ₁

Affiliation

Genome-wide association studies (GWAS) have made substantial contributions to our understanding of complex neurodegenerative diseases. For example, the largest GWAS of Alzheimer's disease so far has identified 19 loci in addition to APOE and revealed key pathways of disease pathogenesis, including inflammation and immune response, lipid metabolism, and endocytosis.¹ Similarly, two GWAS of Parkinson's disease have uncovered 41 loci and suggested a major role of autophagy and lysosomal biology in Parkinson's disease risk.

中文翻译：

路易体痴呆的遗传结构正在形成

全基因组关联研究 (GWAS) 为我们理解复杂的神经退行性疾病做出了重大贡献。例如，迄今为止最大的阿尔茨海默病 GWAS 已经确定了除APOE之外的 19 个位点，并揭示了疾病发病机制的关键途径，包括炎症和免疫反应、脂质代谢和内吞作用。¹同样，帕金森病的两个 GWAS 发现了 41 个位点，并表明自噬和溶酶体生物学在帕金森病风险中的主要作用。

更新日期：2017-12-16

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