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Tailoring the mechanical and biodegradable properties of binary blends of biomedical thermoplastic elastomer
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2017-12-15 , DOI: 10.1016/j.jmbbm.2017.12.013
Hui Ying Ang , Jingni Chan , Daniel Toong , Subbu S. Venkatraman , Sing Joo Chia , Ying Ying Huang

Blending polymers with complementary properties capitalizes on the inherent advantages of both components, making it possible to tailor the behaviour of the resultant material. A polymer blend consisting of an elastomer and thermoplastic can help to improve the mechanical integrity of the system without compromising on its processibility. A series of blends of biodegradable Poly(L-lactide-co-ɛ-caprolactone) (PLC) and Poly-(l,l-lactide-co-glycolic acid) (PLLGA), and PLC with Poly-(d,l-lactide-co-glycolic acid) (PDLLGA) were evaluated as a potential material for a biodegradable vesicourethral connector device. Based on the Tg of the blends, PLC/PLLGA formed an immiscible mixture while PLC/PDLLGA resulted in a compatible blend. The results showed that with the blending of PLC, the failure mode of PLLGA and PDLLGA changed from brittle to ductile fracture, with an significant decreas in tensile modulus and strength. SEM images demonstrated the different blend morphologies of different compositions during degradation. Gel Permeation Chromatography (GPC) and mechanical characterization revealed the degradation behaviour of the blends in this order (fastest to slowest): PDLLGA and PLC/PDLLGA blends > PLLGA and PLC/PLLGA blends > PLC. The PLC/PLLGA (70:30) blend was recommended as a suitable for the vesicourethral connector device application, highlighting the tailoring of blends to achieve a desired mechanical performance.



中文翻译:

量身定制生物医学热塑性弹性体二元共混物的机械和生物降解性能

具有互补特性的共混聚合物可利用两种组分的固有优势,从而可以调整所得材料的性能。由弹性体和热塑性塑料组成的聚合物共混物可以帮助改善系统的机械完整性,而不会影响其可加工性。一系列可生物降解的聚(L-丙交酯-ω-己内酯)(PLC)和聚(l,l-丙交酯-乙醇酸)(PLLGA)的共混物,以及具有Poly-(d,l-丙交酯(乙醇酸)(PDLLGA)被评估为可生物降解的膀胱尿道连接器设备的潜在材料。基于共混物的Tg,PLC / PLLGA形成不混溶的混合物,而PLC / PDLLGA产生了相容的共混物。结果表明,通过PLC的混合,PLLGA和PDLLGA的破坏模式从脆性断裂变为韧性断裂,拉伸模量和强度均显着下降。SEM图像显示了降解期间不同组成的不同共混物形态。凝胶渗透色谱法(GPC)和机械表征显示混合物的降解行为按此顺序(最快到最慢):PDLLGA和PLC / PDLLGA混合物> PLLGA和PLC / PLLGA混合物> PLC。PLC / PLLGA(70:

更新日期:2017-12-15
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