The effect of anthracene-based chalcone derivatives in the resazurin dye reduction assay mechanisms for the investigation of Gram-positive and Gram-negative bacterial and fungal infection†,New Journal of Chemistry

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The effect of anthracene-based chalcone derivatives in the resazurin dye reduction assay mechanisms for the investigation of Gram-positive and Gram-negative bacterial and fungal infection†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2017-12-15 00:00:00 , DOI: 10.1039/c7nj04125j
Gopi Prakash _{1,

2,

3,

4} , Mani Boopathy _{1,

2,

3,

4} , Ramasamy Selvam _{1,

2,

3,

4} , Samuel Johnsanthosh Kumar _{1,

2,

3,

4} , Kathavarayan Subramanian _{1,

2,

3,

4}

Affiliation

A novel series of anthracene-based chalcone derivatives (ANNP, ANMNP, ANFL, ANAT, ANID, ANPT and ANTP) containing naphthalene, 6-methoxy naphthalene, fluorene, anthracene, indole, phenothiazine and thiophene were synthesized and evaluated in terms of their antibacterial and antifungal activities. Most of the synthesized compounds showed potent inhibitory activity towards various bacteria and fungi with minimum inhibitory concentrations (MICs) ranging from 0.39 to 100 μg mL⁻¹. Their antibacterial and antifungal activities have been evaluated using a resazurin dye reduction assay method. These compounds showed moderate to good antibacterial and antifungal activities. Compounds ANNP, ANFL, ANID and ANPT were found to be the most potent with an MIC value of 3.12 (μg mL⁻¹) against bacterial strains Bacillus cereus and Staphylococcus aureus. Compounds ANFL and ANAT also exhibited the same inhibitory activity with a MIC value of 3.12 (μg mL⁻¹) against the fungal strains Candida albicans and Candida cruzi while the remaining compounds showed moderate to weak activities as compared to the corresponding standard drugs.

中文翻译：

蒽基查尔酮衍生物在刃天青素染料还原试验机制中对革兰氏阳性和革兰氏阴性细菌和真菌感染的研究的作用†

一种新的系列基于蒽的查耳酮衍生物的（ANNP，ANMNP，ANFL，ANAT，ANID，ANPT和ANTP）含萘，6-甲氧基萘，芴，蒽，吲哚，噻嗪和噻吩的合成和评价了它们的抗菌方面和抗真菌活动。大多数合成的化合物对各种细菌和真菌均表现出有效的抑制活性，最低抑制浓度（MIC）为0.39至100μgmL ^-1。已使用刃天青染料还原测定法评估了它们的抗菌和抗真菌活性。这些化合物显示出中等至良好的抗菌和抗真菌活性。化合物ANNP，ANFL，ANID和ANPT被认为是最有效的具有3.12的MIC值（微克毫升^-1针对细菌菌株）蜡状芽孢杆菌和金黄色葡萄球菌。化合物ANFL和ANAT也显示出相同的抑制活性的3.12 MIC值（微克毫升^-1对抗真菌菌株）白色念珠菌和念珠菌锥虫 而其余的化合物与相应的标准药物相比，显示出中等至弱的活性。

更新日期：2017-12-15

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