Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography,Analytical Methods

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Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography
Analytical Methods ( IF 2.7 ) Pub Date : 2017-12-14 00:00:00 , DOI: 10.1039/c7ay02696j
Rabin Neupane _{1,

2,

3,

4,

5} , Malin Källsten _{1,

2,

3,

4,

5} , Fredrik Lehmann _{5,

6,

7} , Jonas Bergquist _{1,

2,

3,

4,

5}

Affiliation

In this study, the effect of mobile phase composition for size exclusion chromatography (SEC) on antibody drug conjugate (ADC) aggregate analysis was investigated. The use of organic components as well as high ionic strength during aggregate analysis was demonstrated to be advantageous.

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