Chemoselective triazole-phosphonamidate conjugates suitable for photorelease,Chemical Communications

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Chemoselective triazole-phosphonamidate conjugates suitable for photorelease
Chemical Communications ( IF 4.3 ) Pub Date : 2017-12-14 00:00:00 , DOI: 10.1039/c7cc08605a
Kristina D. Siebertz _{1,

2,

3,

4,

5} , Christian P. R. Hackenberger _{1,

2,

3,

4,

5}

Affiliation

Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.

中文翻译：

适于光释放的化学选择性三唑-膦酰胺酸酯偶联物

在这里，我们描述了一种新的共轭含叠氮化物目标化合物的方法，该目标化合物可以通过用近紫外光照射而容易地作为胺类释放出来。该概念基于使用化学选择性CuAAC和Staudinger-膦酸酯反应的两步方案，从2-硝基苄基取代的亚膦酸酯开始以高收率递送光可裂解的膦酰胺酸酯共轭物。

更新日期：2018-01-18

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