Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been instrumental for the development of powerful imaging tools that are still used in the clinics, it is now clear that mitochondria play a key role in oncogenesis. Besides exerting central bioenergetic functions, mitochondria provide indeed building blocks for tumor anabolism, control redox and calcium homeostasis, participate in transcriptional regulation, and govern cell death. Thus, mitochondria constitute promising targets for the development of novel anticancer agents. However, tumors arise, progress, and respond to therapy in the context of an intimate crosstalk with the host immune system, and many immunological functions rely on intact mitochondrial metabolism. Here, we review the cancer cell-intrinsic and cell-extrinsic mechanisms through which mitochondria influence all steps of oncogenesis, with a focus on the therapeutic potential of targeting mitochondrial metabolism for cancer therapy.

中文翻译：

---

线粒体代谢与癌症。

糖酵解长期以来被认为是癌细胞能量产生和合成代谢生长的主要代谢过程。尽管这种观点有助于开发仍在临床中使用的强大成像工具，但现在很清楚线粒体在肿瘤发生中发挥着关键作用。除了发挥中心生物能功能外，线粒体确实为肿瘤合成代谢提供了基础材料，控制氧化还原和钙稳态，参与转录调节，并控制细胞死亡。因此，线粒体构成了新型抗癌药物开发的有希望的靶标。然而，肿瘤的产生、进展和对治疗的反应是在与宿主免疫系统密切相互作用的背景下进行的，并且许多免疫功能依赖于完整的线粒体代谢。在这里，我们回顾了线粒体影响肿瘤发生所有步骤的癌细胞内在和细胞外机制，重点关注靶向线粒体代谢的癌症治疗潜力。