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Pimentelamines A–C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-12-13 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00587
Luke P. Robertson 1, 2 , Sandra Duffy 2 , Yun Wang 3 , Dongdong Wang 2 , Vicky M. Avery 2 , Anthony R. Carroll 1, 2, 3
Affiliation  

Three members of a new class of ascorbic acid-adduct indole alkaloids (13), a new prenylated indole alkaloid (4), and five known compounds (59) were isolated from the leaves of Flindersia pimenteliana. The structures of 14 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC50 values ranging from 0.19 to 3.6 μM.

中文翻译:

Pimentelamines A–C,从澳大利亚树Flindersia pimenteliana的叶子中分离出来的吲哚生物碱

一类新的抗坏血酸加合物吲哚生物碱(的三个成员1 - 3),一个新的异戊二烯化吲哚生物碱(4),和五个已知的化合物(5 - 9)从叶片分离巨盘木属pimenteliana。的结构1 - 4分别鉴定它们的(+)的基础上- HRESIMS和2D NMR光谱数据。还报道了天然产物对氯喹敏感(3D7)和耐氯喹(Dd2)恶性疟原虫的抗血浆活性,IC 50值为0.19至3.6μM。
更新日期:2017-12-13
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