Synthesis ( IF 2.2 ) Pub Date : 2017-12-13 , DOI: 10.1055/s-0036-1591738 Elena Krasnokutskaya , Alexey Chudinov , Victor Filimonov
Abstract
The diazotization of a series of N-oxides of aminopyridines and aminoquinolines under the action of sodium nitrite in the presence of KI and p-TsOH in water at room temperature leads to the formation of the corresponding N-oxides of iodopyridines and iodoquinolines in high yields. The method has a general character and can be used for the preparation of 3-, 2-, and 4- N-oxides of iodopyridines.
The diazotization of a series of N-oxides of aminopyridines and aminoquinolines under the action of sodium nitrite in the presence of KI and p-TsOH in water at room temperature leads to the formation of the corresponding N-oxides of iodopyridines and iodoquinolines in high yields. The method has a general character and can be used for the preparation of 3-, 2-, and 4- N-oxides of iodopyridines.
中文翻译:
在水中对甲苯磺酸存在下,通过杂环氨基N-氧化物的重氮化-碘化反应,可以合成碘,吡啶和碘代喹啉的N-氧化物
摘要
在室温下水中,在KI和p -TsOH存在下,在亚硝酸钠的作用下,亚硝酸钠作用下,一系列氨基吡啶和氨基喹啉的N-氧化物重氮化导致碘代吡啶和碘喹啉的相应N-氧化物的高收率形成。 。该方法具有一般性,可用于制备碘吡啶的3-,2-和4- N-氧化物。
在室温下水中,在KI和p -TsOH存在下,在亚硝酸钠的作用下,亚硝酸钠作用下,一系列氨基吡啶和氨基喹啉的N-氧化物重氮化导致碘代吡啶和碘喹啉的相应N-氧化物的高收率形成。 。该方法具有一般性,可用于制备碘吡啶的3-,2-和4- N-氧化物。