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TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions
Synthesis ( IF 2.2 ) Pub Date : 2017-12-13 , DOI: 10.1055/s-0036-1591733
Laurent El Kaïm 1 , Laurence Grimaud 2 , Maxime Vitale 3 , Sudipta Ponra 2, 3 , Aude Nyadanu 1, 2 , Sylvie Maurin 2
Affiliation  

Abstract

The isocyanide insertion into sulfanyl-phthalides under Lewis acid conditions is reported with full details. This sequential three-component reaction affords a new straightforward and highly convenient method for the preparation of 3-amino-4-sulfanyl isocoumarins, the potential of which is still unexplored.

The isocyanide insertion into sulfanyl-phthalides under Lewis acid conditions is reported with full details. This sequential three-component reaction affords a new straightforward and highly convenient method for the preparation of 3-amino-4-sulfanyl isocoumarins, the potential of which is still unexplored.



中文翻译:

TiCl4介导的异氰酸酯插入反应合成3,4-杂双取代的香豆素

摘要

报道了在路易斯酸条件下将异氰酸酯插入到硫烷基-邻苯二甲酸酯中的详细信息。这种顺序的三组分反应为制备3-氨基-4-硫烷基异香豆素提供了一种新的直接且高度方便的方法,该方法的潜力尚未得到开发。

报道了在路易斯酸条件下将异氰酸酯插入到硫烷基-邻苯二甲酸酯中的详细信息。这种顺序的三组分反应为制备3-氨基-4-硫烷基异香豆素提供了一种新的直接且高度方便的方法,该方法的潜力尚未得到开发。

更新日期:2017-12-13
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