Synthesis ( IF 2.2 ) Pub Date : 2017-12-13 , DOI: 10.1055/s-0036-1589149 Lúcia de Aguiar , Marcio de Mattos , Carlos Sanabria , Bruno Costa , Gil Viana
Abstract
A simple and efficient methodology for the direct halogenation of N-phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N-phenylureas with different patterns of substitution. Additionally, less reactive N-benzylureas were halogenated in the presence of a mixture of trifluoroacetic acid and acetonitrile at room temperature.
A simple and efficient methodology for the direct halogenation of N-phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N-phenylureas with different patterns of substitution. Additionally, less reactive N-benzylureas were halogenated in the presence of a mixture of trifluoroacetic acid and acetonitrile at room temperature.
中文翻译:
三卤代异氰尿酸对不对称N-苄基和N-苯基脲的高效直接卤化反应
摘要
在室温下,使用三卤异氰尿酸在乙腈中开发了一种简单有效的方法,用于直接卤化N-苯基脲。该方案被证明对于构建具有不同取代模式的N-苯基脲是有效的。另外,在室温下,在三氟乙酸和乙腈的混合物存在下,将反应性较低的N-苄基脲卤化。
在室温下,使用三卤异氰尿酸在乙腈中开发了一种简单有效的方法,用于直接卤化N-苯基脲。该方案被证明对于构建具有不同取代模式的N-苯基脲是有效的。另外,在室温下,在三氟乙酸和乙腈的混合物存在下,将反应性较低的N-苄基脲卤化。