Lake Ellasjøen on the remote Norwegian island of Bjørnøya is populated by Arctic charr (Salvelinus alpinus) having 20-fold higher body burdens of polychlorinated biphenyls (PCB) compared to charr from the neighboring Lake Laksvatn. This provides a natural setting to test the hypothesis that lifelong exposure to PCBs compromises the energy metabolism in this northernmost living salmonid. To test this, blood was sampled from charr from both lakes immediately after capture and following a 1 h handling and confinement stressor to assess possible differences in their energy metabolism and energy substrate mobilization, respectively. The plasma metabolome of charr was assessed by metabolite detection/separation with LC-MS. Plasma metabolite profiles revealed differences in key pathways involved in amino acid metabolism between charr from each lake, underscoring an impact of PCBs on energy metabolism in Arctic charr residing in Lake Ellasjøen. Subjecting charr from either lake to an acute stressor altered the plasma metabolite profiles and revealed distinct stress metabolome in Lake Ellasjøen charr, suggesting a reduced metabolic capacity. Taken together, lifelong exposure to PCBs in Ellasjøen charr disrupts the plasma metabolome, and may impair the adaptive metabolic response to stressors, leading to a reduced fitness.

中文翻译：

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挪威远距离北极地区终生暴露于多氯联苯会破坏北极鲨鱼的血浆应激代谢组。

北极比尔（Salvelinus alpinus）居住在偏远的挪威比约尔纳岛（Bjørnøya）上的Ellasjøen湖）所含的多氯联苯（PCB）的负担比邻近的拉克斯瓦湖（Lake Laksvatn）的炭渣高20倍。这为检验以下假设提供了自然环境：长期暴露于多氯联苯会损害这种最北端的活鲑鱼的能量代谢。为了测试这一点，在捕获后立即在两个湖泊的炭黑中抽取血液，并在处理和限制压力1小时后分别评估其能量代谢和能量底物动员的可能差异。通过使用LC-MS进行代谢物检测/分离来评估charr的血浆代谢组。血浆代谢物谱揭示了来自每个湖泊的炭r之间氨基酸代谢关键途径的差异，强调了多氯联苯对居住在Ellasjøen湖中的北极炭r能量代谢的影响。使任一湖中的炭黑都经受急性应激源的作用会改变血浆代谢产物的分布，并揭示出Ellasjøen炭黑湖中独特的应激代谢物，这表明其代谢能力降低。综上所述，埃拉斯霍恩查尔（Ellasjøencharr）终生暴露于多氯联苯会破坏血浆代谢组，并可能削弱对应激源的适应性新陈代谢反应，从而导致适应性降低。