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A Numerical Study on the Effect of Particle Surface Coverage on the Quartz Crystal Microbalance Response
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1021/acs.analchem.7b04607 Jurriaan J. J. Gillissen 1, 2 , Joshua A. Jackman 1, 2 , Seyed R. Tabaei 1, 2 , Nam-Joon Cho 1, 2, 3
Analytical Chemistry ( IF 6.7 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1021/acs.analchem.7b04607 Jurriaan J. J. Gillissen 1, 2 , Joshua A. Jackman 1, 2 , Seyed R. Tabaei 1, 2 , Nam-Joon Cho 1, 2, 3
Affiliation
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The quartz crystal microbalance (QCM) is a surface-sensitive measurement technique to characterize adsorption processes at solid–fluid interfaces. While QCM measurements are routinely applied to study homogeneous thin films, characterizing heterogeneous films of adsorbed particles remains challenging because QCM is sensitive to not only the mass of adsorbed particles but also to that of hydrodynamically coupled fluid. To extract information about adsorbed particles, it is necessary to model these hydrodynamic effects, however, current QCM models are restricted to the limit of either a very low surface coverage or to the extrapolated limit of saturation coverage. Herein, we investigated QCM measurement responses in the intermediate surface coverage regime, by conducting lattice Boltzmann simulations of monodisperse, spherical particles that are attached to an oscillating surface. From the simulations, we relate the overtone-dependent QCM frequency and bandwidth shifts to particle size, interparticle distance, and the relevant hydrodynamic length scale. The corresponding results are in qualitative agreement with experimental QCM data for sub-100 nm, gel-phase liposomes. Furthermore, the data provide a theoretical basis for extracting particle sizes from QCM data in the high surface coverage limit.
中文翻译：
颗粒表面覆盖度对石英晶体微平衡响应影响的数值研究
石英晶体微量天平（QCM）是一种表面敏感的测量技术，用于表征固液界面处的吸附过程。虽然QCM测量通常用于研究均质薄膜，但表征吸附颗粒的异质膜仍然具有挑战性，因为QCM不仅对吸附颗粒的质量敏感，而且对流体动力耦合流体的质量敏感。要提取有关吸附颗粒的信息，必须对这些流体动力效应进行建模，但是，当前的QCM模型仅限于非常低的表面覆盖率的极限或饱和覆盖率的外推极限。在这里，我们通过进行单分散的格子Boltzmann模拟，研究了在中间表面覆盖范围内的QCM测量响应，附着在振动表面上的球形颗粒。从模拟中，我们将泛音相关的QCM频率和带宽偏移与粒径，粒子间距离以及相关的流体力学长度尺度相关联。相应的结果与低于100 nm的凝胶相脂质体的实验QCM数据在质量上吻合。此外，该数据为从高表面覆盖范围的QCM数据中提取粒径提供了理论基础。
更新日期：2018-01-12
中文翻译：
颗粒表面覆盖度对石英晶体微平衡响应影响的数值研究
石英晶体微量天平（QCM）是一种表面敏感的测量技术，用于表征固液界面处的吸附过程。虽然QCM测量通常用于研究均质薄膜，但表征吸附颗粒的异质膜仍然具有挑战性，因为QCM不仅对吸附颗粒的质量敏感，而且对流体动力耦合流体的质量敏感。要提取有关吸附颗粒的信息，必须对这些流体动力效应进行建模，但是，当前的QCM模型仅限于非常低的表面覆盖率的极限或饱和覆盖率的外推极限。在这里，我们通过进行单分散的格子Boltzmann模拟，研究了在中间表面覆盖范围内的QCM测量响应，附着在振动表面上的球形颗粒。从模拟中，我们将泛音相关的QCM频率和带宽偏移与粒径，粒子间距离以及相关的流体力学长度尺度相关联。相应的结果与低于100 nm的凝胶相脂质体的实验QCM数据在质量上吻合。此外，该数据为从高表面覆盖范围的QCM数据中提取粒径提供了理论基础。
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