Antimicrobial and Antifouling Strategies for Polymeric Medical Devices,ACS Macro Letters

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Antimicrobial and Antifouling Strategies for Polymeric Medical Devices
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-12-14 00:00:00 , DOI: 10.1021/acsmacrolett.7b00879
Zachary K Zander ₁ , Matthew L Becker ₁

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Hospital-acquired infections arising from implanted polymeric medical devices continue to pose a significant challenge for medical professionals and patients. Often times, these infections arise from biofilm accumulation on the device, which is difficult to eradicate and usually requires antibiotic treatment and device removal. In response, significant efforts have been made to design functional polymeric devices or coatings that possess antimicrobial or antifouling properties that limit biofilm formation and subsequent infection by inhibiting or eliminating bacteria near the device surface or by limiting the initial attachment of proteins and bacteria. In this Viewpoint, we highlight the magnitude of device-associated infections, the role of biofilm formation in human pathogenesis, and recent advances in antimicrobial and antifouling polymers, as well as current strategies employed in commercial devices for preventing infection.

中文翻译：

高分子医疗器械的抗菌和防污策略

由植入聚合物医疗器械引起的医院获得性感染继续对医疗专业人员和患者构成重大挑战。通常，这些感染是由设备上的生物膜积聚引起的，这很难根除，通常需要抗生素治疗和设备移除。作为回应，已经做出重大努力来设计具有抗菌或防污性能的功能性聚合物装置或涂层，通过抑制或消除装置表面附近的细菌或通过限制蛋白质和细菌的初始附着来限制生物膜的形成和随后的感染。在这个观点中，我们强调了器械相关感染的严重程度、生物膜形成在人类发病机制中的作用，以及抗菌和防污聚合物的最新进展，

更新日期：2017-12-14

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