Wound healing is a multipart and dynamic process of replacing devitalized and damaged cellular structures and tissue layers. Numerous conventional wound dressings are employed for the management of wounds but there is a lack of absolute and versatile choice. An ideal wound healing modality should provide a moist environment, offer protection from secondary infections, eliminate wound exudate, and stimulate tissue regeneration. Hyaluronic acid (HA) has been known to promote angiogenesis, granulation tissue formation, remodeling of extracellular matrix (ECM), and wound healing. Accumulation and turnover of ECM is a hallmark of tissue injury, repair, and remodeling in wound healing. HA is a major component of ECM and plays an important role in regulating tissue injury, accelerating tissue repair, and controlling disease outcomes. A wide range of in vitro, in vivo, and clinical studies have demonstrated the wound healing efficacy of HA-based biomaterials not only in the treatment of wound in the tympanic membrane, skin, and articular cartilage but also in tracheal and corneal wound healing. Recent progress and improved therapeutic efficacy achieved through partial modification and formation of HA-based biomaterials, including HA-scaffolds, sponge-like hydrogels, anti-adhesive sheets, cultured dermal substitutes, thin membranes, and dermal matrix grafts have been discussed. The current review summarizes the evidence for the therapeutic effectiveness of HA-based biomaterials in the treatment of traumatic, surgical, and chronic wounds and tissue regeneration.

中文翻译：

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透明质酸为基础的生物材料：组织再生和治疗创伤，外科和慢性伤口的多功能和智能方法。

伤口愈合是更换失活和受损的细胞结构和组织层的多部分动态过程。许多常规的伤口敷料用于伤口处理，但是缺乏绝对和通用的选择。理想的伤口愈合方式应提供潮湿的环境，提供对继发感染的保护，消除伤口渗出液，并刺激组织再生。透明质酸（HA）可以促进血管生成，肉芽组织形成，细胞外基质（ECM）重塑和伤口愈合。ECM的积累和周转是伤口愈合中组织损伤，修复和重塑的标志。HA是ECM的主要组成部分，在调节组织损伤，加速组织修复和控制疾病预后方面起着重要作用。范围广泛的体外，体内和临床研究已经证明，基于HA的生物材料的伤口愈合功效不仅可以治疗鼓膜，皮肤和关节软骨的伤口，还可以用于气管和角膜伤口的愈合。已经讨论了通过部分修饰和形成HA基生物材料（包括HA支架，海绵状水凝胶，抗粘片，培养的真皮替代物，薄膜和真皮基质移植物）获得的最新进展和改善的治疗功效。当前的综述总结了基于HA的生物材料在治疗创伤，手术和慢性伤口以及组织再生方面的治疗效果的证据。