A new poly[bis(octafluoropentoxy) phosphazene] (OFP) was synthesized for the purpose of blood contacting medical devices. OFP was further either developed into crosslinkable polyphosphazene (X-OFP) or blended with polyurethane (PU) as the mixture (OFP/PU) for improvement of mechanical property of polyphosphazene polymers. All the materials were fabricated as smooth films or further textured with submicron pillars for the assay of antimicrobial and antithrombotic properties. Results showed that crosslinkable OFP (X-OFP) and blends of OFP/PU successfully improved the mechanical strength of OFP and fewer defects of pillars were found on the textured polyphosphazene surfaces. The antithrombotic experiments showed that polyphosphazene OFP materials reduced human Factor XII activation and platelet adhesion, thereby being resistant to plasma coagulation and thrombosis. The bacterial adhesion and biofilm experiments demonstrated that OFP materials inhibited staphylococcal bacterial adhesion and biofilm formation. The surface texturing further reduced the platelet adhesion and bacterial adhesion, and inhibited biofilm formation up to 23 days. The data suggested that textured OFP materials may provide a practical approach to improve the biocompatibility of current biomaterials in the application of blood contacting medical devices with significant reduction in risk of pathogenic infection and thrombosis.

Statement of Significance

The thromboembolic events and microbial infection have been the significant barriers for the long term use of biomaterials in blood-contacting medical devices. The development of new materials with multiple functions including anti-thrombosis and antibacterial surfaces is a high research priority. This study synthesized new biostable and biocompatible polyphosphazene polymers, poly[bis(octafluoropentoxy)phosphazene] (OFP) and crosslinkable OFP, and successfully improved the mechanical strength of polyphosphazenes. Polymers were fabricated into textured films with submicron pillars on the surfaces. The antimicrobial and antithrombotic assays demonstrated that new materials combined with surface physical modification have significant reduction in risk of pathogenic infection and thrombosis, and improve the biocompatibility of current biomaterials in the application of blood-contacting medical devices. It would be interest to biomaterials and bioengineering related communities.

为了与血液接触医疗设备，合成了一种新的聚[双（八氟戊氧基）磷腈]（OFP）。将OFP进一步开发为可交联的聚磷腈（X-OFP）或与聚氨酯（PU）混合在一起作为混合物（OFP / PU），以改善聚磷腈聚合物的机械性能。所有材料均制成光滑的薄膜，或进一步制成带有亚微米支柱的纹理，用于测定抗微生物和抗血栓性质。结果表明，可交联的OFP（X-OFP）和OFP / PU的共混物成功地提高了OFP的机械强度，并且在纹理化的聚磷腈表面上发现的柱子缺陷更少。抗血栓形成实验表明，聚磷腈OFP材料可减少人XII因子的活化和血小板粘附，从而抵抗血浆凝结和血栓形成。细菌粘附和生物膜实验表明，OFP材料可抑制葡萄球菌细菌粘附和生物膜形成。表面纹理进一步降低了血小板粘附和细菌粘附，并在长达23天的时间内抑制了生物膜的形成。数据表明，织构化的OFP材料可以提供一种实用的方法，以在与血液接触的医疗设备的应用中改善当前生物材料的生物相容性，从而显着降低病原体感染和血栓形成的风险。并在长达23天的时间内抑制了生物膜的形成。数据表明，织构化的OFP材料可以提供一种实用的方法，以在与血液接触的医疗设备的应用中改善当前生物材料的生物相容性，从而显着降低病原体感染和血栓形成的风险。并在长达23天的时间内抑制了生物膜的形成。数据表明，织构化的OFP材料可以提供一种实用的方法，以在与血液接触的医疗设备的应用中改善当前生物材料的生物相容性，从而显着降低病原体感染和血栓形成的风险。

重要声明

血栓栓塞事件和微生物感染已成为在接触血液的医疗设备中长期使用生物材料的重大障碍。具有多种功能（包括抗血栓形成和抗菌表面）的新材料的开发是研究的重中之重。这项研究合成了新型的生物稳定和生物相容性的聚磷腈聚合物，聚[双（八氟戊氧基）磷腈]（OFP）和可交联的OFP，并成功提高了聚磷腈的机械强度。将聚合物制成表面带有亚微米柱的纹理膜。抗菌和抗血栓形成试验表明，新材料与表面物理修饰相结合，可显着降低病原体感染和血栓形成的风险，并在接触血液的医疗设备的应用中提高当前生物材料的生物相容性。生物材料和生物工程相关社区将对此感兴趣。