Magnetic nanoporous silica particles (MNS) with spherical morphology and 100 nm particle with advanced characteristics suitable for nanomedicine purposes were synthesized. The obtained nanoparticles were modified with SO₃H groups in a two-step post synthesis procedure. An anticancer drug, mitoxantrone (MTX), and an anti-inflammatory drug, prednisolone (PRD), were loaded on the silica support. The mitoxantrone loaded MNS-SO₃H nanoparticles were coated by chitosan and then prednisolone was infused in the chitosan layer. A second layer of alginate was then applied around the prednisolone and mitoxantrone containing formulation. All materials were characterized by XRD, N₂ physisorption, Mössbauer spectroscopy, magnetization measurements and transmission electron microscopy in order to demonstrate that by the applied preparation method around 11 nm sized maghemite crystals embedded in spherical mesoporous silica nanoparticles were obtained with high pore volume and surface area. Thermal gravimetric analysis, ATR FT-IR spectroscopy and in vitro release experiments proved that MTX and PRD were successfully loaded on the silica matrix. Alginate coating further improved the release properties by preventing the burst release of MTX and PRD. The cytotoxicity properties of the drugs loaded formulations and their ability to retain the intrinsic pharmacological properties of the encapsulated drugs were investigated on a panel of human tumor cell lines.

合成了具有球形形态的磁性纳米多孔二氧化硅颗粒（MNS）和具有适合纳米医学目的的先进特性的100 nm颗粒。在两步后合成过程中，将获得的纳米颗粒用SO ₃ H基团进行修饰。将抗癌药米托蒽醌（MTX）和抗炎药泼尼松龙（PRD）装载在二氧化硅载体上。负载米托蒽醌的MNS-SO ₃ H纳米颗粒被壳聚糖包被，然后泼尼松龙被注入壳聚糖层中。然后将第二层藻酸盐施加在含有泼尼松龙和米托蒽醌的制剂周围。所有材料均经XRD，N ₂表征物理吸附，穆斯堡尔光谱，磁化强度测量和透射电子显微镜，以证明通过应用的制备方法，可以得到大约11 nm大小的嵌在球形介孔二氧化硅纳米颗粒中的磁赤铁矿晶体，且孔体积和表面积均很高。热重分析，ATR FT-IR光谱和体外释放实验证明，MTX和PRD已成功加载到二氧化硅基质上。海藻酸盐涂层通过防止MTX和PRD的突然释放进一步改善了释放性能。在一组人类肿瘤细胞系上研究了载有药物的制剂的细胞毒性特性及其保留被包封药物的固有药理特性的能力。