Neocortical neurons tend to be coactive in groups called ensembles. However, sometimes, individual neurons also spike alone, independent of the ensemble. What processes regulate the transition between individual and cooperative action? Inspired by classical work in biochemistry, we apply the concept of neuronal cooperativity to explore this question. With a focus on neocortical inhibitory interneurons, we offer a working definition of neuronal cooperativity, review its recorded incidences and proposed mechanisms, and describe experimental approaches that will demonstrate and further describe this action. We suggest that cooperativity of “neuron teams” is manifested in vivo through their coactivity, as well as via the action of individual “soloist neurons” in the low end of the sigmoidal cooperativity curve. Finally, we explore the evidence for and implications of individual and team action of neurons.

新皮层神经元倾向于在称为“合奏”的组中发挥积极作用。但是，有时单个神经元也独立于集合而尖峰。哪些过程调节着个人行动与合作行动之间的过渡？受经典的生物化学研究的启发，我们应用神经元协作性的概念来探索这个问题。我们着重于新皮层抑制性中间神经元，提供了神经元协同作用的有效定义，回顾了其记录的发病率和拟议的机制，并描述了将证明并进一步描述该作用的实验方法。我们建议通过神经元的协同作用，以及通过在乙状结肠协作性曲线下端的单个“独奏神经元”的作用，在体内表现出“神经元团队”的协同作用。最后，