Here we explore the combination of constant and oscillatory fields applied in a single device to affect the continuous separation and filtering of ions based on their mobilities. The device explored allows confining and manipulating ions utilizing a combination of radio frequency (rf), direct current (DC) fields, and traveling waves (TW) in a structures for lossless ion manipulations (SLIM) module. We have investigated theoretically and experimentally a concept for continuous filtering of ions based on their mobilities where ions are mobility separated and selected by passage through two regions, both of which incorporated combined TW and constant fields providing opposing forces on the ions. The SLIM module was composed of two surfaces with mirror-image arrays of electrodes and had two regions where the different TW and opposing DC fields could be applied. The filtering capabilities are determined by the applied DC gradient and the TW parameters, such as speed, amplitude, and the TW sequence (i.e., the duty cycle of the traveling wave). The effects of different parameters on the sensitivity and the ion mobility (IM) resolution of the device have been investigated. By appropriately choosing the DC gradient and TW parameters for the two sections, it is possible to transmit ions of a selected mobility while filtering out others of both higher and lower mobility. The novel device described here provides a basis for the targeted analysis of compounds based upon the continuous selection of ions according to their mobility and without the need for high electric fields or pulsed injection.

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在这里，我们探索在单个设备中应用的恒定场和振荡场的组合，以影响基于离子迁移率的离子的连续分离和过滤。探索的设备允许利用射频（rf），直流（DC）场和行波（TW）的组合来限制和操纵离子，该结构用于无损离子操纵（SLIM）模块。我们已经在理论上和实验上研究了基于离子的迁移率连续过滤离子的概念，其中离子被迁移并通过两个区域进行迁移并被选择，两个区域都结合了TW和恒定磁场，在离子上提供了相反的作用力。SLIM模块由两个带有电极镜像阵列的表面组成，并具有两个区域，可以在其中施加不同的TW和相反的DC场。滤波能力由所应用的DC梯度和TW参数（例如速度，幅度和TW序列（即，行波的占空比））确定。已经研究了不同参数对设备的灵敏度和离子迁移率（IM）分辨率的影响。通过适当地选择DC梯度和TW参数为两个部分，所以能够选择的移动性的发射离子，同时滤除其它较高和较低迁移率两者的。

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