No Clinical Benefit of Empirical Antimicrobial Therapy for Pediatric Diarrhea in a High-Usage, High-Resistance Setting,Clinical Infectious Diseases

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No Clinical Benefit of Empirical Antimicrobial Therapy for Pediatric Diarrhea in a High-Usage, High-Resistance Setting
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2017-09-26 , DOI: 10.1093/cid/cix844
Vu Thuy Duong _{1,

2} , Ha Thanh Tuyen ₁ , Pham Van Minh ₁ , James I Campbell ₁ , Hoang Le Phuc ₂ , Tran Do Hoang Nhu ₁ , Le Thi Phuong Tu _{1,

3} , Tran Thi Hong Chau ₁ , Le Thi Quynh Nhi _{1,

4} , Nguyen Thanh Hung ₂ , Nguyen Minh Ngoc ₅ , Nguyen Thi Thanh Huong ₅ , Lu Lan Vi ₆ , Corinne N Thompson ₇ , Guy E Thwaites _{1,

7} , Ruklanthi de Alwis _{1,

7} , Stephen Baker _{1,

7,

8}

Affiliation

Pediatric diarrheal disease presents a major public health burden in low- to middle-income countries. The clinical benefits of empirical antimicrobial treatment for diarrhea are unclear in settings that lack reliable diagnostics and have high antimicrobial resistance (AMR).

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