A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound these associations.

中文翻译：

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通过一种新方法来解决疟疾暴露中的异质性，从而确定针对恶性疟原虫的免疫相关保护

识别候选疟疾疫苗的主要标准是证明对他们获得的免疫力与疾病防护相关。被研究者的年龄，不同种类的疟疾暴露以及维持基线免疫应答的假设都可能使这些关联混淆。