The choice of antibiotics for systemic infections in patients with a high risk of Clostridium difficile infection (CDI) remains a clinical practice dilemma. Although some studies suggest that tetracyclines may be associated with a lower risk of CDI than other antibiotics, other results are conflicting. We conducted a systematic review and metaanalysis of studies that assessed the risk of CDI with tetracyclines compared to other antibiotics.

中文翻译：

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四环素对原发性艰难梭菌感染的低风险：系统评价和荟萃分析

对于难辨梭状芽胞杆菌感染（CDI）高风险患者的全身感染，选择抗生素仍然是临床实践的两难选择。尽管一些研究表明四环素可能比其他抗生素具有更低的CDI风险，但其他结果却相互矛盾。我们对研究评估了四环素与其他抗生素相比的CDI风险进行了系统的综述和荟萃分析。