Purpose

The purpose of this study was to correlate magnetic resonance imaging (MRI) radiographic results with histopathologic growth patterns of metastatic uveal melanoma (UM) to the liver.

Design

Clinicopathologic correlation.

Participants

Patients with metastatic UM to the liver.

Methods

A retrospective review of MRI images of patients with metastatic UM to the liver at a single institution between 2004 and 2016 was performed. The MRI growth patterns were classified as nodular or diffuse. The histopathologic findings of core liver biopsies of liver metastases identified by needle localization in a subset of these patients were reviewed. The core samples were evaluated by routine light microscopy, including immunohistochemical/immunofluorescent staining for CD31, CD105, and HMB45, and classified as exhibiting an infiltrative or nodular growth pattern.

Main Outcome Measures

Magnetic resonance images and core biopsy findings.

Results

A total of 32 patients were identified with metastatic UM to the liver that was imaged by MRI, and 127 lesions were identified. A total of 46 lesions were classified by MRI as infiltrative and 81 as nodular. There were 9 needle-localized core biopsies that corresponded to MRI of metastatic lesions. Of these 9 lesions, 3 that were classified as infiltrative on MRI exhibited stage I infiltrative histologic growth patterns; of the remaining 6 that were classified as nodular by MRI, 5 histologically demonstrated stage II or stage III infiltrative growth patterns and 1 histologically demonstrated a nodular growth pattern.

Conclusions

Magnetic resonance imaging of hepatic infiltrative growth patterns of metastatic UM corresponded to stage I histologic infiltrative growth in the sinusoidal spaces, whereas MRI nodular growth patterns corresponded to stage II/III histologic infiltrative growth that replaced the hepatic lobule or histologic nodular growth in the portal triad that effaced adjacent hepatic parenchyma.

中文翻译：

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转移性葡萄膜黑色素瘤与肝脏不同生长模式的放射学和组织病理学相关性

目的

本研究的目的是将磁共振成像 (MRI) 影像学结果与转移性葡萄膜黑色素瘤 (UM) 的肝脏组织病理学生长模式相关联。

设计

临床病理相关性。

参与者

UM转移到肝脏的患者。

方法

对 2004 年至 2016 年间在单个机构中转移到肝脏的 UM 患者的 MRI 图像进行了回顾性研究。MRI 生长模式分为结节性或弥漫性。回顾了在这些患者的一个亚组中通过针定位确定的肝转移的核心肝活检的组织病理学发现。核心样品通过常规光学显微镜进行评估，包括对 CD31、CD105 和 HMB45 的免疫组织化学/免疫荧光染色，并分类为表现出浸润性或结节性生长模式。

主要观察指标

磁共振图像和核心活检结果。

结果

共有 32 名患者被确定为转移性 UM 到肝脏的 MRI 成像，并确定了 127 个病灶。共有 46 个病灶被 MRI 分类为浸润性，81 个病灶为结节性。有 9 个针定位的核心活检对应于转移病灶的 MRI。在这 9 个病灶中，3 个在 MRI 上被归类为浸润性的表现出 I 期浸润性组织学生长模式；在 MRI 归类为结节的其余 6 例中，5 例组织学证实为 II 期或 III 期浸润性生长模式，1 例组织学证实为结节性生长模式。

结论

转移性 UM 的肝脏浸润性生长模式的磁共振成像对应于肝窦腔中的 I 期组织学浸润性生长，而 MRI 结节生长模式对应于替代肝小叶的 II/III 期组织学浸润性生长或门脉三联征中的组织学结节性生长抹去了邻近的肝实质。