Background

Statins are among the most commonly used medications in the United States, and statin use is associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). However, previous studies are limited by lack of adjustment for important confounders.

Objective

Examine the relation between statins and skin cancer risk in the Nurses' Health Study and Health Professionals Follow-up Study.

Methods

Cox proportional hazards regression was used to evaluate associations.

Results

During follow-up (2000-2010), we documented 10,201 BCC, 1393 SCC, and 333 melanoma cases. History of high cholesterol level was not associated with risk of BCC (pooled multivariable-adjusted hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.00-1.09), SCC (HR, 0.95; 95% CI, 0.85-1.06), or melanoma (HR, 0.87; 95% CI, 0.64-1.19). Statin use was not associated with risk of BCC (HR, 1.04; 95% CI, 0.99-1.09]), SCC (HR, 1.08; 95% CI, 0.94-1.24), or melanoma (HR, 1.04; 95% CI, 0.78-1.38). There was a trend toward higher BCC risk with longer duration of statin use in men (P trend = .003) but not in women (P trend = .86).

Limitations

Lack of treatment data.

Conclusion

History of high cholesterol level was not associated with skin cancer risk. Longer duration of statin use was associated with a trend toward higher BCC risk in men.

中文翻译：

---

他汀类药物的使用和皮肤癌的风险

背景

他汀类药物是美国最常用的药物之一，他汀类药物的使用会增加基底细胞癌（BCC）和鳞状细胞癌（SCC）的风险。但是，由于缺乏对重要混杂因素的调整，以前的研究受到了限制。

客观的

在护士健康研究和健康专业人员跟进研究中检查他汀类药物与皮肤癌风险之间的关系。

方法

使用Cox比例风险回归来评估关联。

结果

在随访期间（2000-2010年），我们记录了10201例BCC，1393例SCC和333例黑色素瘤病例。高胆固醇史与BCC风险无关（合并多变量校正风险比[HR]为1.04； 95％置信区间[CI]为1.00-1.09），SCC（HR为0.95； 95％CI为0.85- 1.06）或黑色素瘤（HR，0.87； 95％CI，0.64-1.19）。他汀类药物的使用与BCC（HR，1.04; 95％CI，0.99-1.09]），SCC（HR，1.08; 95％CI，0.94-1.24）或黑色素瘤（HR，1.04; 95％CI， 0.78-1.38）。在男性中使用他汀类药物的持续时间越长，BCC风险越高的趋势（P趋势= 0.003），在女性中则没有（P趋势= 0.86）。

局限性

缺乏治疗数据。

结论

高胆固醇水平的病史与皮肤癌风险无关。他汀类药物使用时间的延长与男性BCC风险升高的趋势有关。