Background

Statins are among the most commonly used medications in the United States, and statin use is associated with increased risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). However, previous studies are limited by lack of adjustment for important confounders.

Objective

Examine the relation between statins and skin cancer risk in the Nurses' Health Study and Health Professionals Follow-up Study.

Methods

Cox proportional hazards regression was used to evaluate associations.

Results

During follow-up (2000-2010), we documented 10,201 BCC, 1393 SCC, and 333 melanoma cases. History of high cholesterol level was not associated with risk of BCC (pooled multivariable-adjusted hazard ratio [HR], 1.04; 95% confidence interval [CI], 1.00-1.09), SCC (HR, 0.95; 95% CI, 0.85-1.06), or melanoma (HR, 0.87; 95% CI, 0.64-1.19). Statin use was not associated with risk of BCC (HR, 1.04; 95% CI, 0.99-1.09]), SCC (HR, 1.08; 95% CI, 0.94-1.24), or melanoma (HR, 1.04; 95% CI, 0.78-1.38). There was a trend toward higher BCC risk with longer duration of statin use in men (P trend = .003) but not in women (P trend = .86).

Limitations

Lack of treatment data.

Conclusion

History of high cholesterol level was not associated with skin cancer risk. Longer duration of statin use was associated with a trend toward higher BCC risk in men.

中文翻译：

---

他汀类药物的使用和皮肤癌的风险

 背景

他汀类药物是美国最常用的药物之一，他汀类药物的使用与基底细胞癌 (BCC) 和鳞状细胞癌 (SCC) 的风险增加有关。然而，之前的研究因缺乏对重要混杂因素的调整而受到限制。

 客观的

在护士健康研究和健康专业人员随访研究中检查他汀类药物与皮肤癌风险之间的关系。

 方法

Cox 比例风险回归用于评估关联性。

 结果

在随访期间（2000-2010 年），我们记录了 10,201 例基底细胞癌、1393 例鳞状细胞癌和 333 例黑色素瘤病例。高胆固醇水平史与 BCC 风险无关（汇总多变量调整风险比 [HR]，1.04；95% 置信区间 [CI]，1.00-1.09）、SCC（HR，0.95；95% CI，0.85- 1.06），或黑色素瘤（HR，0.87；95% CI，0.64-1.19）。他汀类药物的使用与基底细胞癌（HR，1.04；95% CI，0.99-1.09]）、鳞状细胞癌（HR，1.08；95% CI，0.94-1.24）或黑色素瘤（HR，1.04；95% CI， 0.78-1.38）。男性使用他汀类药物的时间越长，BCC 风险就越高（ P趋势 = .003），但女性则不然（ P趋势 = .86）。

 局限性

 缺乏治疗数据。

 结论

高胆固醇水平史与皮肤癌风险无关。较长的他汀类药物使用时间与男性 BCC 风险较高的趋势相关。