The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders. By providing information on a broad spectrum of brain disorders, experimental methods, and scientific approaches using both larval and adult zebrafish, the review is intended to showcase this underutilized laboratory species for behavioral neuroscience and psychopharmacology research.

斑马鱼代表了系统复杂性和实用性之间的极佳折衷，这些特性使其可用于复杂脑部疾病的建模和机械分析。筛选对幼虫和成年斑马鱼行为有影响的精神活性药物的方法也很有希望。这篇评论基于2016年IBNS大会上最近举行的一次研讨会，就如何利用斑马鱼推进对人类中枢神经系统疾病的研究提供了不同的观点。首先讨论斑马鱼研究中的一个重要瓶颈，测量该物种的行为（特别是浅滩捕捞），然后继续进行有关幼虫斑马鱼自闭症谱系障碍研究的实例，以及筛选天然产物中成年斑马鱼具有精神活性的化合物的实例。 ，以及关于斑马鱼胎儿酒精光谱失调模型的开发。通过提供有关使用幼虫和成年斑马鱼的广泛的脑部疾病，实验方法和科学方法的信息，该综述旨在展示这种未充分利用的实验室物种，用于行为神经科学和心理药理学研究。