The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury” which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.

本综述的目的是讨论题为“实验性中枢神经系统损伤治疗策略和挑战的当前进展”研讨会上提出的研究，该研讨会在 2016 年国际行为神经科学学会年会上提出。在此，我们讨论弥漫性和局灶性创伤性脑损伤 (TBI) 和随之而来的慢性行为缺陷以及潜在的康复方法。我们还讨论了 TBI 后压力对执行功能的影响以及内分泌系统的反应和调节反馈机制。还讨论了中枢神经系统损伤后内源性大麻素的作用。最后，我们讨论了抗精神病药物和抗癫痫药物，这些药物分别用于控制 TBI 引起的躁动和癫痫发作。审查主要包括已发布的数据。