Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug’s long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual’s lifespan and even into the subsequent generation. Though mechanistic investigations regarding the consequences of developmental cannabis exposure remain sparse, human and animal studies have begun to reveal specific epigenetic disruptions in the brain and the periphery. In this article, we focus attention on long-term disturbances in epigenetic regulation in relation to prenatal, adolescent and parental germline cannabinoid exposure. Expanding knowledge about the protracted molecular memory could help to identify novel targets to develop preventive strategies and treatments for behaviors relevant to neuropsychiatric risks associated with developmental cannabis exposure.

关于大麻（Cannabis spp）的广泛争论仍在继续，大麻是全世界许多国家最常用的非法物质。过去二十年来，大麻研究呈指数级增长，但该药物的长期影响仍缺乏深入的科学数据。表观基因组是一种关键的分子机制，能够维持大麻素诱导的基因表达和行为的持续改变，这种改变在个体的整个生命周期甚至下一代中都被观察到。尽管有关发育期大麻暴露后果的机制研究仍然很少，但人类和动物研究已开始揭示大脑和外周特定的表观遗传破坏。在本文中，我们重点关注与产前、青少年和父母生殖系大麻素暴露相关的表观遗传调控的长期紊乱。扩展关于持久分子记忆的知识可能有助于确定新的目标，以制定与发育性大麻暴露相关的神经精神风险相关行为的预防策略和治疗方法。