Callous-unemotional traits – the insensitivity to other’s welfare and well-being – are characterized by a lack of empathy. They are characteristic of psychopathy and can be found in other anti-social disorders, such as conduct disorder. Because of the increasing prevalence of anti-social disorders and the rising societal costs of violence and aggression, it is of great importance to elucidate the psychological and physiological mechanisms underlying callousness in the search for pharmacological treatments. One promising avenue is to create a relevant animal model to explore the neural bases of callousness. Here, we review recent advances in rodent models of pro-social choice that could be applied to probe the absence of pro-sociality as a proxy of callous behavior, and provide future directions for the exploration of the neural substrates of callousness.

对他人的福利和福祉不敏感的无情的性格特征是缺乏同情心。它们是精神病的特征，可以在其他反社会疾病（例如行为障碍）中发现。由于反社会疾病的患病率上升以及暴力和侵略的社会成本上升，因此在寻找药理治疗方法时阐明其残酷性的心理和生理机制非常重要。一种有前途的途径是创建一个相关的动物模型，以探索call的神经基础。在这里，我们回顾了亲社会选择的啮齿动物模型的最新进展，这些模型可以用于探究亲社会性的缺失作为亲情行为的代名词，