Conduct disorder (CD) is a moderately heritable psychiatric disorder of childhood and adolescence characterized by aggression toward people and animals, destruction of property, deceitfulness or theft, and serious violation of rules. Genome-wide scans using linkage and association methods have identified a number of suggestive genomic regions that are pending replication. A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist. Studies of gene-environment interplay show that CD genetic predispositions also contribute to selection into higher-risk environments, and that environmental factors can alter the importance of CD genetic factors and differentially methylate CD candidate genes. The field's understanding of CD etiology will benefit from larger, adequately powered studies in gene identification efforts; the incorporation of polygenic approaches in gene-environment interplay studies; attention to the mechanisms of risk from genes to brain to behavior; and the use of genetically informative data to test quasi-causal hypotheses about purported risk factors.

中文翻译：

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遗传对品行障碍的影响。


行为障碍（CD）是一种中度遗传性儿童和青少年精神障碍，其特征是对人和动物的攻击、破坏财产、欺骗或盗窃以及严重违反规则。使用连锁和关联方法的全基因组扫描已经识别出许多有待复制的暗示性基因组区域。在独立研究中，少数候选基因（例如 GABRA2、MAOA、SLC6A4、AVPR1A）与 CD 相关表型相关；然而，复制失败的情况也存在。基因与环境相互作用的研究表明，CD 遗传倾向也有助于选择进入高风险环境，并且环境因素可以改变 CD 遗传因素的重要性并差异甲基化 CD 候选基因。该领域对 CD 病因学的理解将受益于基因鉴定工作中更大规模、更有力的研究；将多基因方法纳入基因-环境相互作用研究；关注从基因到大脑再到行为的风险机制；以及使用遗传信息数据来测试有关所谓风险因素的准因果假设。