Interleukin (IL)-17A is a pro-inflammatory cytokine in mice and humans. It is recognized as a key factor for the protection of mice against various pathogens, but it also underlies pathogenic inflammatory responses in numerous mouse models. The inborn errors of IL-17A- and IL-17F-mediated immunity identified in humans in the last decade have revealed that IL-17A and IL-17F are key players in mucocutaneous immunity to Candida albicans, and, to a lesser extent, Staphylococcus aureus. By contrast, there is currently no genetic evidence for a causal link between excess of IL-17 and autoimmunity, autoinflammation, or allergy in humans. We discuss here the physiological and pathological roles of mouse and human IL-17A and IL-17F in host defense and excessive inflammation. We highlight recent advances in our understanding of the consequences of deficient or excessive IL-17 immunity at various mucocutaneous sites, including the oral cavity, skin, intestine, lungs, and vagina.

中文翻译：

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小鼠和人类的皮肤粘膜 IL-17 免疫：宿主防御与过度炎症。


白细胞介素 (IL)-17A 是小鼠和人类的促炎细胞因子。它被认为是保护小鼠免受各种病原体侵害的关键因素，但它也是许多小鼠模型中致病性炎症反应的基础。过去十年在人类中发现的 IL-17A 和 IL-17F 介导的免疫先天性错误表明，IL-17A 和 IL-17F 是皮肤粘膜对白色念珠菌免疫的关键参与者，在较小程度上也是对葡萄球菌的免疫。金黄色葡萄球菌。相比之下，目前没有遗传证据表明 IL-17 过量与人类自身免疫、自身炎症或过敏之间存在因果关系。我们在此讨论小鼠和人类 IL-17A 和 IL-17F 在宿主防御和过度炎症中的生理和病理作用。我们重点介绍了我们对各种皮肤粘膜部位（包括口腔、皮肤、肠道、肺和阴道）IL-17 免疫力不足或过度的后果的理解的最新进展。