DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides†,Organic & Biomolecular Chemistry

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DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-12-12 00:00:00 , DOI: 10.1039/c7ob02860a
Akkharaphong Thupyai _{1,

2,

3,

4,

5} , Chaleena Pimpasri _{1,

2,

3,

4,

5} , Sirilata Yotphan _{1,

2,

3,

4,

5}

Affiliation

A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(I) acetate, the C–S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.

中文翻译：

DABCO催化的吡唑啉酮与二芳基二硫化物的银促进的直接巯基化†

描述了用于N-取代的吡唑啉酮与二芳基二硫化物的直接硫醇化的高效方案。使用DABCO和乙酸银（I）的组合，在室温下在温和且易于处理的条件下，C–S键的形成可以顺利进行。这种合成策略为安替比林和其他吡唑啉酮底物提供了方便而直接的修饰，从而以中等到极好的收率提供了一系列芳基硫醚取代的吡唑啉酮产品。

更新日期：2017-12-12

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