Interaction of Aβ1–42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy,Nanoscale

当前位置： X-MOL 学术 › Nanoscale › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Interaction of Aβ1–42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy
Nanoscale ( IF 5.8 ) Pub Date : 2017-12-13 00:00:00 , DOI: 10.1039/c7nr07489a
S. Henry _{1,

2,

3,

4,

5} , N. B. Bercu _{4,

6,

7,

8,

9} , C. Bobo _{9,

10,

11,

12} , C. Cullin _{1,

2,

3,

4,

5} , M. Molinari _{9,

10,

11,

12} , S. Lecomte _{1,

2,

3,

4,

5}

Affiliation

Toxicity of Aβ peptides involved in Alzheimer's disease is linked to the interaction of intermediate species with membranes. Nanoscale Infrared Spectroscopy enhances the study of the morphology and the secondary structure of the peptides as fibers or oligomers interacting with membranes of different compositions, with nanometer scale resolution. Membrane models are used to investigate the role of different lipids in their interactions with Aβ peptides. This work clearly brings to light that the presence of cholesterol in membranes is favorable to the interaction with Aβ peptides in oligomers or aggregates.

中文翻译：

Aβ的相互作用_1-42肽或它们与不同组成的模型膜变体探测由红外线nanospectroscopy

涉及阿尔茨海默氏病的Aβ肽的毒性与中间物种与膜的相互作用有关。纳米级红外光谱技术以纳米级分辨率提高了纤维或低聚物与不同成分的膜相互作用时肽的形态和二级结构的研究。膜模型用于研究不同脂质在它们与Aβ肽相互作用中的作用。这项工作清楚地表明，膜中胆固醇的存在有利于寡聚体或聚集体中与Aβ肽的相互作用。

更新日期：2017-12-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11