Effects of polysaccharides from purple sweet potatoes on immune response and gut microbiota composition in normal and cyclophosphamide treated mice,Food & Function

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Effects of polysaccharides from purple sweet potatoes on immune response and gut microbiota composition in normal and cyclophosphamide treated mice
Food & Function ( IF 5.1 ) Pub Date : 2017-12-13 00:00:00 , DOI: 10.1039/c7fo01302g
Chao Tang _{1,

2,

3,

4} , Jian Sun _{2,

4,

5,

6,

7} , Bo Zhou _{1,

2,

3,

4} , Changhai Jin _{1,

2,

3,

4} , Jun Liu _{1,

2,

3,

4} , Juan Kan _{1,

2,

3,

4} , Chunlu Qian _{1,

2,

3,

4} , Nianfeng Zhang _{1,

2,

3,

4}

Affiliation

In this study, three polysaccharides including water-soluble polysaccharide (WSP), dilute alkali-soluble polysaccharide (DASP) and concentrated alkali-soluble polysaccharide (CASP) were extracted from purple sweet potatoes and then administered to normal and cyclophosphamide (CTX) treated mice by gavage. The results showed that WSP and CASP could restore the spleen index and immune cytokine (IL-2 and IL-6) levels in CTX treated mice, while DASP could enhance the levels of TNF-α, IL-2 and IL-6. As compared to the normal control group, WSP and CASP treatment groups exhibited increased levels of Bacteroidetes, Lachnospiraceae and Oscillospira, but decreased levels of Firmicutes, Alcaligenaceae and Sutterella in normal mice. When compared with a model control group, all the three polysaccharide treatment groups showed relatively higher abundances of Bacteroidetes, Ruminococcaceae, Lachnospiraceae, Ruminococcus and Oscillospira but lower levels of Firmicutes, Proteobacteria, Alcaligenaceae and Sutterella in CTX treated mice. Moreover, all the polysaccharides could enhance the production of acetic acid, propionic acid and butyric acid in normal mice, while WSP could upregulate the production of these short chain fatty acids in CTX treated mice.

中文翻译：

紫色番薯多糖对正常和环磷酰胺治疗的小鼠免疫应答和肠道菌群组成的影响

在这项研究中，从紫色甘薯中提取了水溶性多糖（WSP），稀碱溶性多糖（DASP）和浓碱溶性多糖（CASP）三种多糖，然后分别给予正常和环磷酰胺（CTX）处理的小鼠通过管饲。结果表明，WSP和CASP可以恢复CTX处理的小鼠的脾脏指数和免疫细胞因子（IL-2和IL-6）水平，而DASP可以提高TNF-α，IL-2和IL-6的水平。相比于正常对照组，WSP和CASP治疗组表现出增加水平的拟杆菌，毛螺和Oscillospira，但降低的水平厚壁菌门，Alcaligenaceae和正常小鼠中的沙门氏菌。当与模型对照组相比，所有三个治疗多糖组显示的相对丰度更高拟杆菌，Ruminococcaceae，毛螺，瘤胃球菌属和Oscillospira但较低水平的厚壁菌门，变形菌，Alcaligenaceae和Sutterella在CTX处理的小鼠。此外，所有多糖均可以增强正常小鼠中乙酸，丙酸和丁酸的产生，而WSP可以上调CTX处理小鼠中这些短链脂肪酸的产生。

更新日期：2017-12-13

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