Synthesis ( IF 2.2 ) Pub Date : 2017-12-12 , DOI: 10.1055/s-0036-1591859 Franz Bracher , Katharina Vögerl , Duc Ong
Abstract
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
中文翻译:
烯醇醚对芳香胺和N-杂环的还原N-芳基乙基化
摘要
以(2-甲氧基乙烯基)(杂)芳烃为结构单元,以三乙基硅烷/三氟乙酸为还原剂,开发了一种在温和的还原条件下芳族胺和杂环的N-芳基乙基化的简便方法。该协议可与许多官能团兼容,并且脂肪族胺由于质子化而呈惰性。
以(2-甲氧基乙烯基)(杂)芳烃为结构单元,以三乙基硅烷/三氟乙酸为还原剂,开发了一种在温和的还原条件下芳族胺和杂环的N-芳基乙基化的简便方法。该协议可与许多官能团兼容,并且脂肪族胺由于质子化而呈惰性。