Polyethylenimine-Modified Fluorescent Carbon Dots As Vaccine Delivery System for Intranasal Immunization,ACS Biomaterials Science & Engineering

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Polyethylenimine-Modified Fluorescent Carbon Dots As Vaccine Delivery System for Intranasal Immunization
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-12-27 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00370
Sha Li ₁ , Zhong Guo ₁ , Guandi Zeng ₂ , Yu Zhang ₁ , Wei Xue ₁ , Zonghua Liu ₁

Affiliation

Fluorescent carbon dots (CDs) as a luminescent nanomaterial have obtained much attention in the biomedical field. To make good use of their luminescent property and nanoscaled size, we developed CDs as a vaccine delivery system for intranasal immunization in this work. To this aim, polyethylenimine-modified CDs were prepared via a simple microwave method. Intranasal immunization was performed by using the CDs as an antigen carrier to deliver model protein antigen ovalbumin. The results showed that the CDs as an intranasal vaccine delivery system enhanced the immunization efficacy by significantly increasing IgG titer, IgA induction in the local and distant mucous membrane sites, splenocyte proliferation, cytokine IFN-γ secretion by splenocytes, and memory T cells. From the results, the CDs could be used as vaccine delivery systems with the advantage of tracing the antigen transportation from administration site to the lymph organs.

中文翻译：

聚乙烯亚胺修饰的荧光碳点作为用于鼻内免疫的疫苗输送系统

荧光碳点（CDs）作为发光纳米材料已在生物医学领域引起了广泛关注。为了充分利用它们的发光特性和纳米级尺寸，我们在这项工作中开发了CD作为鼻内免疫的疫苗递送系统。为此，通过简单的微波方法制备了聚乙烯亚胺改性的CD。通过使用CD作为抗原载体进行模型内抗原卵清蛋白的递送，进行鼻内免疫。结果表明，CD可以作为鼻内疫苗输送系统，通过显着提高IgG滴度，在局部和远处的粘膜部位诱导IgA，脾细胞增殖，脾细胞分泌的细胞因子IFN-γ和记忆T细胞来增强免疫效果。从结果来看

更新日期：2017-12-27

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