Modulating Anticancer Potential by Modifying the Structural Properties of a Family of Zinc Metal–Organic Chains Based on 4-Nitro-1H-pyrazole,Crystal Growth & Design

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Modulating Anticancer Potential by Modifying the Structural Properties of a Family of Zinc Metal–Organic Chains Based on 4-Nitro-1H-pyrazole
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2017-12-28 00:00:00 , DOI: 10.1021/acs.cgd.7b01443
Belén Fernández ₁ , Ignacio Fernández ₂ , Javier Cepeda ₃ , Marta Medina-O’Donnell ₄ , Eva E. Rufino-Palomares ₄ , Álvaro Raya-Barón ₂ , Santiago Gómez-Ruiz ₅ , Amalia Pérez-Jiménez ₄ , José Antonio Lupiáñez ₄ , Fernando J. Reyes-Zurita ₄ , Antonio Rodríguez-Diéguez ₁

Affiliation

We have synthesized a novel family of metal–organic chains based on 4-nitro-1H-pyrazole linker and zinc as metal center. We report the formation of these coordination polymers using hydrothermal routes with water as solvent. These materials display one-dimensional structures with major structural modifications from minimal synthetic variations. What is more interesting, we have carried out antitumor measurements, and we have related these properties with the structural networks. To the best of our knowledge, these materials constitute the first examples of polymeric structures for 4-NO₂-pz ligands. NMR and MS spectrometry were used to verify the characterization of the metal complexes in solution to corroborate that these materials are present in the biological assays.

中文翻译：

通过修改基于4-硝基-1 H-吡唑的锌金属-有机链族的结构特性来调节抗癌潜力

我们基于4-硝基-1 H-吡唑连接体和以锌为金属中心合成了一个新颖的金属有机链族。我们报告了使用水为溶剂的水热途径形成这些配位聚合物。这些材料显示一维结构，具有最小化合成变化的主要结构修饰。更有趣的是，我们已经进行了抗肿瘤测量，并将这些特性与结构网络相关联。据我们所知，这些材料构成了4-NO ₂ -pz配体的聚合物结构的第一个例子。NMR和MS光谱法用于验证溶液中金属络合物的特征，以证实这些物质存在于生物学测定中。

更新日期：2017-12-28

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