Fast and Selective Simultaneous Determination of Acetaminophen, Aspirin and Caffeine in Pharmaceutical Products by Batch Injection Analysis with Multiple Pulse Amperometric Detection,Electroanalysis

当前位置： X-MOL 学术 › Electroanalysis › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fast and Selective Simultaneous Determination of Acetaminophen, Aspirin and Caffeine in Pharmaceutical Products by Batch Injection Analysis with Multiple Pulse Amperometric Detection
Electroanalysis ( IF 2.7 ) Pub Date : 2017-12-13 , DOI: 10.1002/elan.201700721
Letícia Machado Alencar ₁ , Rafael Backes dos Santos ₁ , Tiago de Jesus Guedes ₂ , Wallans Torres Pio dos Santos _{2,

3} , João Batista Gomes de Souza ₄ , Valdir Souza Ferreira ₄ , Rodrigo Amorim Bezerra da Silva _{1,

5}

Affiliation

In this work is presented a method for simultaneous determination of paracetamol (PA), acetylsalicylic acid (ASA) and caffeine (CA) in pharmaceutical tablets, using a bare boron‐doped diamond working electrode (BDDE) coupled to batch injection analysis system with multiple pulse amperometric detection (BIA‐MPA). The optimized sequence of fast potential pulses were applied on BDDE for acquisition of independent amperograms: +1.0 V for PA oxidation, +1.3 V for oxidation of PA and salicylic acid (SA) generated from a previous alkaline hydrolysis of ASA and +1.6 V in which the three analytes are oxidized (PA, SA and CA). Selective determination of PA is performed using the currents obtained at +1.0 V, while SA and CA signals are indirectly obtained using simple subtraction operations between peak currents from each amperogram and correction factors (CF's). The limitations of such approach on the precision and accuracy as function of BIA‐MPA conditions are discussed. Simultaneous determination of the target drugs in pharmaceutical tablets was performed by BIA‐MPA and the results compared to a HPLC‐DAD method. Under optimized conditions, the proposed method exhibits fast responses (180 injections per hour for the simultaneous determination of the three analytes) and suitable precision (RSD_PA: 0.78 %; RSD_SA: 1.09 %; RSD_CA: 2.73 %). BIA‐MPA method is simple, portable and presents relative low‐cost.

中文翻译：

分批进样-多脉冲安培检测法快速，选择性地同时测定药品中对乙酰氨基酚，阿司匹林和咖啡因

在这项工作中，提出了一种使用裸硼掺杂金刚石工作电极（BDDE）结合多批次进样分析系统同时测定药物片剂中对乙酰氨基酚（PA），乙酰水杨酸（ASA）和咖啡因（CA）的方法脉冲安培检测（BIA-MPA）。优化的快速电势脉冲序列应用于BDDE，以获取独立的电流图：+1.0 V用于PA氧化，+1.3 V用于PA和由以前的ASA碱水解产生的水杨酸（SA）氧化，+ 1.6 V在三种分析物被氧化（PA，SA和CA）。使用在+1.0 V时获得的电流进行PA的选择性确定，SA和CA信号是通过使用每个电流图的峰值电流与校正因子（CF's）之间的简单减法运算间接获得的。讨论了这种方法对BIA-MPA条件的精度和准确性的局限性。通过BIA-MPA同时测定药物片剂中的目标药物，并将结果与HPLC-DAD方法进行比较。在最佳条件下，所提出的方法显示出快速响应（每小时180次进样，可同时测定三种分析物）和合适的精密度（RSD）通过BIA-MPA同时测定药物片剂中的目标药物，并将结果与HPLC-DAD方法进行比较。在最佳条件下，所提出的方法显示出快速响应（每小时180次进样，可同时测定三种分析物）和合适的精密度（RSD）通过BIA-MPA同时测定药物片剂中的目标药物，并将结果与HPLC-DAD方法进行比较。在最佳条件下，所提出的方法显示出快速响应（每小时180次进样，可同时测定三种分析物）和合适的精密度（RSD）_PA：0.78％；RSD _SA：1.09％; RSD _CA：2.73％）。BIA-MPA方法简单，可移植且成本较低。

更新日期：2017-12-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11