Notch signaling: A sweet strategy

Notch signaling: A sweet strategy, Published online: 12 December 2017; doi:10.1038/nchembio.2532

Glycosylation of Notch receptors regulates ligand-induced Notch signaling, which is essential for normal development in animals. Fucose analogs targeting Notch glycosylation serve as ligand-specific Notch inhibitors and facilitate the understanding of how O-glycan regulates Notch–ligand interactions.

中文翻译：

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陷波信号：一种不错的策略

陷波信号：一种不错的策略

陷波信号：一种不错的策略，在线发布：2017年12月12日；doi：10.1038 / nchembio.2532

Notch受体的糖基化调节配体诱导的Notch信号传导，这对于动物的正常发育至关重要。靶向Notch糖基化的岩藻糖类似物可作为配体特异性Notch抑制剂，有助于理解O-聚糖如何调节Notch-配体相互作用。