A Pd/Mn bimetal system was found to be an effective catalyst for dehydration of aldoximes to the useful nitriles under mild aerobic conditions. Different to the known metal‐catalyzed aldoxime dehydration reactions, this reaction very possibly proceeded via an alternative mechanism of Pd/Mn bimetal relay catalysis involving a Mn‐catalyzed aerobic oxidation of aldoximes to nitrile oxides by air and a Pd‐catalyzed oxygen transfer from the nitrile oxides to the solvent acetonitrile. This method tolerates a variety of substrates including sterically bulky ones and also the natural product derivative.

中文翻译：

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Pd / Mn双金属中继催化好氧醛肟肟脱水制丁腈

发现Pd / Mn双金属系统是在温和的好氧条件下醛糖肟脱水为有用的腈的有效催化剂。与已知的金属催化的醛肟脱水反应不同，该反应很可能是通过Pd / Mn双金属中继催化的另一种机理进行的，该机理包括Mn催化的空气中醛肟的好氧氧化为腈氧化物，以及Pd催化的氧转移。氧化丁腈制得溶剂乙腈。该方法可耐受多种底物，包括空间庞大的底物以及天然产物衍生物。