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Not Oligomers but Amyloids are Cytotoxic in the Membrane‐Mediated Amyloidogenesis of Amyloid‐β Peptides
ChemBioChem ( IF 2.6 ) Pub Date : 2018-01-19 , DOI: 10.1002/cbic.201700576
Naoya Itoh 1 , Eri Takada 1 , Kaori Okubo 1 , Yoshiaki Yano 1 , Masaru Hoshino 1 , Akira Sasaki 2 , Masataka Kinjo 3 , Katsumi Matsuzaki 1
Affiliation  

What's your poison? The aggregation processes of Aβ(1–42) on cells and cytotoxic events were investigated. Aβ formed amyloids after forming nontoxic oligomers composed of ≈ten Aβ molecules. The formation of amyloids was necessary to induce apoptosis and reduce the ability of the cell to proliferate; this indicates that amyloid formation is a key event in Aβ‐induced cytotoxicity.
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中文翻译:

不是低聚物,而是淀粉样蛋白在淀粉样β肽的膜介导的淀粉样蛋白生成中具有细胞毒性。

你的毒药是什么?研究了Aβ(1-42)在细胞上的聚集过程和细胞毒性事件。Aβ形成由约10个Aβ分子组成的无毒寡聚体后形成淀粉样蛋白。淀粉样蛋白的形成对于诱导凋亡和降低细胞增殖的能力是必不可少的。这表明淀粉样蛋白的形成是Aβ诱导的细胞毒性的关键事件。
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更新日期:2018-01-19
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