The reduction of ketones with 2-propanol as reductant was achieved using an in-situ generated catalytic system based on manganese pentacarbonyl bromide, as metal precursor, and ethylenediamine as ligand. The reaction proceeds in high yield at 80 °C, in 3 h, with 0.5 mol% of catalyst. In the presence of chiral (1R,2R)-N,N′-dimethyl-1,2-diphenylethane-1,2-diamine, as the ligand, sterically hindered alcohols were produced with enantiomeric excess up to 90%.

中文翻译：

---

锰与（手性）二胺配体催化的酮的实际（不对称）转移氢化

使用原位生成的基于五羰基锰锰作为金属前驱体和乙二胺作为配体的催化体系，可以实现2-丙醇作为还原剂还原酮。使用0.5 mol％的催化剂，反应在80°C下于3小时内以高收率进行。在手性（1 R，2 R）-N，N'-二甲基-1,2-二苯基乙烷-1,2-二胺作为配体的情况下，产生对位异构体过量至多90％的位阻醇。