Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and extracellular RNAs (exRNAs) are emerging groups of regulatory RNAs, which possess low or no protein-coding potential. Emerging lines of evidence indicates that deregulated expression of lncRNAs and circular RNAs are associated with the induction and progression of various cancers, including oral cancer, through epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and functional roles of extracellular RNAs, lncRNAs, and circular RNAs in oral squamous cell carcinoma and discuss their potential clinical applications as diagnostic or prognostic biomarkers, and therapeutic targets.

口腔鳞状细胞癌（OSCC）的特征是基因组和表观基因组改变。但是，口腔鳞状细胞癌的发生和发展的机制尚待阐明。长的非编码RNA（lncRNA），环状RNA（circRNA）和细胞外RNA（exRNA）是新兴的调控RNA组，它们具有低或无蛋白质编码潜力。越来越多的证据表明，通过表观遗传，转录和转录后改变，lncRNA和环状RNA的表达失调与各种癌症（包括口腔癌）的诱导和进展有关。在这篇评论中，我们重点介绍了细胞外RNA，lncRNA的表达和功能，