Pulmonary arterial hypertension (PAH) has a major effect on life expectancy with functional degeneracy of the lungs and right heart. Interleukin-13 (IL-13), one of the type 2 cytokines mainly associated with allergic diseases, has recently been reported to be associated with Schistosomiasis-associated PAH which shares pathological features with other forms of PAH, such as idiopathic PAH and connective tissue disease-associated PAH. But a direct pathological role of IL-13 in the development of PAH has not been explored. We examined the effects of recombinant human IL-13 on the function of primary human pulmonary artery endothelial cells (HPAECs) to examine how IL-13 influences exacerbation of PAH. IL-13 increased the expression of Rictor, which is a key molecule of mammalian target of rapamycin complex 2. Treatment of IL-13 induced HPAEC migration via Rictor. Rictor was directly regulated by both miR-424 and 503 (miR-424/503). Therefore, IL-13 increases Rictor level by regulating miR-424/503, causing the increase of HPAEC migration. Since enhancement of HPAEC migration in the lung is thought to be associated with PAH, these data suggest that IL-13 takes some roles in exacerbating PAH.

肺动脉高压 (PAH) 对预期寿命有重大影响，肺和右心功能退化。白细胞介素 13 (IL-13) 是主要与过敏性疾病相关的 2 型细胞因子之一，最近据报道与血吸虫病相关的多环芳烃有关，后者与其他形式的多环芳烃（如特发性多环芳烃和结缔组织）具有相同的病理特征疾病相关的 PAH。但尚未探索 IL-13 在 PAH 发展中的直接病理作用。我们检查了重组人 IL-13 对原代人肺动脉内皮细胞 (HPAEC) 功能的影响，以检查 IL-13 如何影响 PAH 的恶化。IL-13 增加 Rictor 的表达，Rictor 是哺乳动物雷帕霉素复合物 2 靶标的关键分子。通过 Rictor 处理 IL-13 诱导的 HPAEC 迁移。Rictor 受 miR-424 和 503 (miR-424/503) 直接调节。因此，IL-13 通过调节 miR-424/503 增加 Rictor 水平，导致 HPAEC 迁移增加。由于肺中 HPAEC 迁移的增强被认为与 PAH 相关，这些数据表明 IL-13 在加剧 PAH 中发挥了一些作用。