Combination chemotherapy treatments with polymer drug conjugates (PDCs) have been designed to overcome the limitations of traditional chemotherapy. While there are many significant design challenges associated with engineering a combination therapy with PDCs, several studies have shown therapeutic benefits of incorporating multiple drugs onto a polymeric carrier. Here, we summarize the chemistries and biological performance of different combination PDCs that have been tested in the preclinical setting and offer recommendations for future studies which will provide the necessary information to streamline future translation.

中文翻译：

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工程聚合物偶联物改善联合化疗的研究进展

已设计出将聚合物化学偶联物（PDC）与化学疗法相结合的疗法，以克服传统化学疗法的局限性。尽管与PDC联合疗法的工程设计存在许多重大的设计挑战，但多项研究表明，将多种药物结合到聚合物载体上具有治疗优势。在这里，我们总结了在临床前环境中测试过的不同组合PDC的化学和生物学性能，并为以后的研究提供了建议，这些建议将为简化将来的翻译提供必要的信息。