Certain organochlorine pesticides (OCPs) are designated as persistent organic pollutants and are regulated in many countries. The effects of OCPs on pediatric endocrinology are a concern; however, only limited data exist from human studies on maternal OCP exposure and its effects on infants' hormone levels. This study was conducted as part of the Hokkaido Study Sapporo Cohort, a prospective birth cohort study in Japan. Participants included 514 women who enrolled at 23–35 weeks of gestation between 2002 and 2005; maternal blood samples were collected in late pregnancy, and 29 OCPs were measured. Reproductive and steroid hormone levels in cord blood were also determined. Characteristics of mothers and their infants were obtained from self-administered questionnaires and medical records. Ultimately, 232 samples with both OCP and hormone data were analyzed. Fifteen of 29 investigated OCPs were detected in over 80% of the samples, with p,p′-dichlorodiphenyldichloroethylene showing the highest concentration (median value: 619 pg/g-wet). The association between OCPs and sex hormone levels varied by sex. Linear regression models after sex stratification showed that chlordanes, cis-hexachlorobenzene, heptachlor epoxide, Mirex, and toxaphenes in maternal blood were inversely associated with testosterone, cortisol, cortisone, sex hormone-binding globin, prolactin, and androstenedione-dehydroepiandrosterone (DHEA) and testosterone-androstenediones ratios among boys. Furthermore, these OCPs were positively correlated with DHEA, follicle stimulating hormone (FSH), and adrenal androgen-glucocorticoid and FSH-inhibin B ratios among boys. In categorical quartile models, testosterone and DHEA were inversely and positively associated with OCPs, respectively. Estradiol-testosterone and adrenal androgen-glucocorticoid ratios tended to increase with increasing OCP concentrations in the higher quartile, while the testosterone-androstenedione ratio tended to decrease. Sex hormone-binding globulin and prolactin showed an inverse association with OCPs. Among girls, the linear regression model showed that only p,p′-dichlorodiphenyltrichloroethane was inversely associated with the level of DHEA and the adrenal androgen-glucocorticoid ratio, but was positively associated with cortisone levels. However, no associations were observed using the quartile categorical model. These results suggest that prenatal exposure to OCPs disrupt reproductive hormones of fetuses in utero among boys, even at relatively low levels.

某些有机氯农药（OCP）被指定为持久性有机污染物，并在许多国家/地区受到监管。OCP对儿科内分泌学的影响是一个令人关注的问题。然而，从人类研究中获得的关于母体OCP暴露及其对婴儿激素水平的影响的数据很少。该研究是北海道研究札幌队列研究的一部分，该研究是日本的一项前瞻性出生队列研究。参加者包括514位年龄在23-35岁之间的女性 2002年至2005年之间的妊娠周数；在孕晚期收集母体血样，并测量29种OCP。还确定了脐带血中的生殖激素和类固醇激素水平。母亲和婴儿的特征来自自我管理的问卷和医疗记录。最终，分析了232个同时具有OCP和激素数据的样品。在超过80％的样品中检测到29种OCP，其中有15种被检测到，其中p，p'-二氯二 苯基二氯乙烯的浓度最高（中值：619 pg / g-湿）。OCP和性激素水平之间的关联因性别而异。性别分层后的线性回归模型显示，氯丹，顺孕妇血液中的六氯苯，七氯环氧化物，灭蚁灵和毒杀芬与男孩的睾丸激素，皮质醇，可的松，性激素结合球蛋白，催乳素和雄烯二酮-脱氢表雄酮（DHEA）和睾丸激素-雄烯二酮酮比率成反比。此外，这些OCP与男孩的DHEA，卵泡刺激素（FSH）以及肾上腺雄激素-糖皮质激素和FSH-抑制素B比率呈正相关。在分类四分位数模型中，睾丸激素和DHEA与OCP分别呈负相关和正相关。在较高的四分位数中，随着OCP浓度的增加，雌二醇-睾丸激素和肾上腺雄激素-糖皮质激素的比率趋于增加，而睾丸激素-雄烯二酮的比率趋于下降。性激素结合球蛋白和催乳素与OCP呈负相关。在女孩中，线性回归模型表明，只有p，p'-二氯二苯基三氯乙烷与DHEA水平和肾上腺雄激素-糖皮质激素比率呈负相关，但与可的松水平呈正相关。但是，使用四分位数分类模型未观察到关联。这些结果表明，即使在相对较低的水平下，产前暴露于OCP也会破坏男孩子宫内胎儿的生殖激素。