A lot of efforts have been devoted to engineering the delivery of hydrophobic drugs due to the high demand of chemotherapy against cancer. While early developed liposomes and polymeric nanoparticles did not meet the requirements of high drug loading efficiency, pure drug nanoparticles appeared to meet these together with high stability. Current drug delivery systems demand an improved performance over the whole aspects of stability, loading capacity, and therapeutic effects. As a result, both new techniques based on traditional methods and totally new procedures are under investigation. In this review, we focus on the evaluation of pure drug nanolloids fabricated by different engineering protocols with emphasis on the size and morphology, delivery and controlled release, and therapeutic effects of these drug nanocolloids.

由于对癌症的化学疗法的高需求，已经投入大量努力来设计疏水性药物的递送。尽管早期开发的脂质体和聚合物纳米颗粒无法满足高载药量的要求，但纯药物纳米颗粒似乎可以满足这些要求并具有高稳定性。当前的药物输送系统要求在稳定性，负载能力和治疗效果的整个方面都具有改善的性能。结果，正在研究基于传统方法的新技术和全新的程序。在这篇综述中，我们专注于通过不同的工程规程制造的纯药物纳米脂质的评估，重点是这些药物纳米胶体的大小和形态，递送和控释以及治疗效果。